This book offers profound insights into the intersection of disease, society, and stigma. Firstly, it vividly illustrates the profound fear leprosy inspired, leading to its classification as a highly contagious and incurable disease necessitating segregation. Helps details the evolution of lazarettos, from monastic foundations seeking to separate the afflicted from the healthy out of piety and fear, to later state-sanctioned institutions driven by public health concerns. Secondly, the book humanizes the leper, moving beyond the clinical description to explore their daily struggles, the lack of effective cures available during much of the period, and the immense social ostracization they endured, losing families, livelihoods, and community status. Thirdly, it examines the practical and ethical dimensions of isolation, questioning the effectiveness and humanity of institutional confinement, and highlighting the often-poor conditions and lack of genuine care in many lazarettos. Finally, Helps traces the decline of leprosy in England, partly due to improved living conditions and understanding, leading to the gradual dismantling of the specialized lazaretto system, offering a historical perspective on how diseases and their management change over time.